Colorectal cancer (CRC) ranks as the third most frequent cancer among men and the fourth most common among women. Notably, the occurrence of colorectal polyps, which serve as precursor lesions for CRC, is significantly elevated in older individuals. The objective of this study was to investigate the association between low bone mineral density (BMD) and the presence of colorectal polyps in elderly populations. Utilizing data collected from Wenzhou Central Hospital between January 2020 to August 2023, a retrospective cross-sectional study was conducted. Participants aged 60 years and above who had undergone colonoscopy and dual energy X-ray absorptiometry scan (DEXA) were included in the study. The patients were classified based on low BMD (defined as Osteoporosis/Osteopenia, T-score < −1.0) and clinical threshold. Multivariable logistic regression and propensity score matching analysis (PSM) were employed to calculate the adjusted odds ratios (OR) and 95% confidence intervals (95% CI) for Colorectal Polyps to eliminate potential confounding factors.. A total of 557 subjects were enrolled in the study, with a mean age of 67.53 years. Among these subjects, 346 (62.1%) were diagnosed with colorectal polyps. Multivariate logistic regression analysis revealed that low BMD Group(T-score < −1.0) had an adjusted OR of 0.575 (95% CI = 0.355-0.931, p=0.025) compared to those with normal BMD people. More significant results were observed in the PSM analysis(OR = 0.450, 95% CI = 0.254-0.799, p=0.006). In summary, our findings indicate that low BMD appears to decrease the risk of colorectal polyps in individuals older than 60 years, especially among non-smoker and male. This novel observation has not been previously reported.

Utilizing data collected from Wenzhou Central Hospital between January 2020 to August 2023, a retrospective cross-sectional study was conducted. Participants aged 60 years and above who had undergone colonoscopy and dual energy X-ray absorptiometry scan (DEXA) were included in the study. The patients were classified based on low BMD (defined as Osteoporosis/Osteopenia, T-score < −1.0) and clinical threshold. Multivariable logistic regression and propensity score matching analysis (PSM) were employed to calculate the adjusted odds ratios (OR) and 95% confidence intervals (95% CI) for Colorectal Polyps to eliminate potential confounding factors.

.A total of 557 subjects were enrolled in the study, with a mean age of 67.53 years. Among these subjects, 346 (62.1%) were diagnosed with colorectal polyps. Multivariate logistic regression analysis revealed that low BMD Group(T-score < −1.0) had an adjusted OR of 0.575 (95% CI = 0.355-0.931, p=0.025) compared to those with normal BMD people. More significant results were observed in the PSM analysis(OR = 0.450, 95% CI = 0.254-0.799, p=0.006). 

In summary, our findings indicate that low BMD appears to decrease the risk of colorectal polyps in individuals older than 60 years, especially among non-smoker and male. This novel observation has not been previously reported.