To explore the incidence and clinical significance of fatigue in early RA (duration ≤ 1 year). Exploring the clinical significance of fatigue in patients with early RA, analyzing the factors related to and risk factors for fatigue, and taking active and effective measures to intervene as soon as possible have important clinical significance for patients with early RA.

 A total of 472 cases of early RA and 80 healthy controls matched by sex and age were recruited. The SF-36 was used to assess fatigue in early RA.

 ①The incidence of fatigue in early RA was 63.00%, 44% of the patients with early RA had severe fatigue, and 32% had fatigue as the first symptom. ②There were significant differences in sex, education level, disability, sleep factors and depression between the fatigue and nonfatigue groups of early RA. The joint tenderness, tenderness index, HAQ, VAS and PGA in the early RA fatigue group were higher than those in the nonfatigue group. The level of IL-6 and DAS28 in the early RA fatigue group were significantly higher than those in the nonfatigue group, while the ESR and CRP, RF, and anti-CCP levels were not significantly different. ③Correlation analysis showed that fatigue severity was negatively correlated with education level in early RA and was positively correlated with the level of IL-6 and the DAS28. ④Logistic analysis showed that female sex, joint tenderness, VAS, HAQ and IL-6 levels were independent risk factors for early RA with fatigue.

These results suggest that severe fatigue occurs in early RA. Early RA with fatigue have more obvious joint pain, poorer quality of life and higher disease activity. Patients who need interventions for fatigue may be diagnosed with RA early in the course of the disease.The evaluation of and interventions for fatigue in patients with early RA need to be early and individualized.