【Abstract】Adult Onset Still’s disease (AOSD) is a rare autoinflammatory disorder. It is characterized by high spiking fever, arthralgia or arthritis and evanescent salmon-pink maculopapular rash. However, in some patients with persistent pruritic lesions (PPEs), the lesions do not resolve with defervescence. Moreover, these patients have a more severe condition to progress macrophage activation syndrome (MAS), which significantly raises mortality. Here, we report 3 cases of AOSD patients with PPEs. Providing the clinical features of these persistent pruritic rashes is crucial for the early diagnosis and treatment of AOSD. It can mitigate the progress of MAS and increase patient survival rates.

【Abstract】Adult Onset Still’s disease (AOSD) is a rare autoinflammatory disorder. It is characterized by high spiking fever, arthralgia or arthritis and evanescent salmon-pink maculopapular rash. However, in some patients with persistent pruritic lesions (PPEs), the lesions do not resolve with defervescence. Moreover, these patients have a more severe condition to progress macrophage activation syndrome (MAS), which significantly raises mortality. Here, we report 3 cases of AOSD patients with PPEs. Providing the clinical features of these persistent pruritic rashes is crucial for the early diagnosis and treatment of AOSD. It can mitigate the progress of MAS and increase patient survival rates.

【Abstract】Adult Onset Still’s disease (AOSD) is a rare autoinflammatory disorder. It is characterized by high spiking fever, arthralgia or arthritis and evanescent salmon-pink maculopapular rash. However, in some patients with persistent pruritic lesions (PPEs), the lesions do not resolve with defervescence. Moreover, these patients have a more severe condition to progress macrophage activation syndrome (MAS), which significantly raises mortality. Here, we report 3 cases of AOSD patients with PPEs. Providing the clinical features of these persistent pruritic rashes is crucial for the early diagnosis and treatment of AOSD. It can mitigate the progress of MAS and increase patient survival rates.

【Abstract】Adult Onset Still’s disease (AOSD) is a rare autoinflammatory disorder. It is characterized by high spiking fever, arthralgia or arthritis and evanescent salmon-pink maculopapular rash. However, in some patients with persistent pruritic lesions (PPEs), the lesions do not resolve with defervescence. Moreover, these patients have a more severe condition to progress macrophage activation syndrome (MAS), which significantly raises mortality. Here, we report 3 cases of AOSD patients with PPEs. Providing the clinical features of these persistent pruritic rashes is crucial for the early diagnosis and treatment of AOSD. It can mitigate the progress of MAS and increase patient survival rates.