1.指南来源（Guide Source）:

NCCN临床实践指南:神经母细胞瘤 V1.2025.发布已获NCCN肿瘤学临床实践指南(NCCN指南®)许可。©2025美国国家综合癌症网络公司.保留所有权利。未经NCCN明确的书面许可，不得出于任何目的以任何形式复制NCCN指南®和文中的插图。要查看NCCN指南的最新完整版本，请访问NCCN.org。NCCN指南是一项持续进行的工作，可能会随着新的重要数据的出现而不断完善。 

2.免责声明（Disclaimers）：

NCCN对其内容、使用或应用不做任何形式的担保，并否认以任何方式对其应用或使用承担任何责任。

在下载本篇指南前，请先您详细阅读并同意以下协议：

NCCN内容不得用于商业目的，以及NCCN作为NCCN内容的许可方，不作任何陈述或保证，并明确否认NCCN指南适用于任何特定患者的护理或治疗，任何医院、寻求使用《NCCN指南》治疗患者的临床医生或其他医疗服务提供者(“提供者”)应根据特定患者护理或治疗的具体临床情况做出独立的医疗判断，NCCN不建议、推荐或认可任何提供者(无论是否与被许可方相关)进行任何有偿或无偿的医疗治疗、咨询或服务，也不应因被许可方建议、推荐或认可任何此类提供者的作为或不作为而直接或间接承担责任。详见《NCCN最终用户许可协议》

3.专家名单（Staff）：

Rochelle Bagatell, MD/Chair €

Abramson Cancer Center at the University of Pennsylvania | Children’s Hospital of Philadelphia

Julie R. Park, MD/Vice-Chair €

St. Jude Children's Research Hospital/The University of Tennessee Health Science Center

Sahaja Acharya, MD §

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |Johns Hopkins Children’s Center

Jennifer Aldrink, MD ¶

The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute | Nationwide Children’s Hospital

Jenna Allison, MD €

Fred & Pamela Buffett Cancer Center | Children’s Hospital & Medical Center

Elizabeth Alva, MD, MSPH €

O'Neal Comprehensive Cancer Center at UAB | Children’s of Alabama

Carola Arndt, MD €

Mayo Clinic Comprehensive Cancer Center

Melissa Bear, MD ‡

Indiana University Melvin and Bren Simon Comprehensive Cancer Center | Riley Children’s

Health

Daniel Benedetti, MD, MA €

Vanderbilt-Ingram Cancer Center | Monroe Carell Jr. Children's Hospital at Vanderbilt

Erin Brown, MD ¶

UC Davis Comprehensive Cancer Center

Steve Cho, MD ɸ

University of Wisconsin Carbone Cancer Center | American Family Children’s Hospital

Alanna Church, MD ≠

Dana-Farber/Brigham and Women's Cancer Center | Mass General Cancer Center | Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

Andrew Davidoff, MD ¶

St. Jude Children's Research Hospital/The University of Tennessee Health Science Center

Ami Desai, MD, MSCE ‡ €

The UChicago Medicine Comprehensive Cancer Center

Steven DuBois, MD, MS €

Dana-Farber/Brigham and Women's Cancer Center | Mass General Cancer Center | Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

Douglas Fair, MD, MS €

Huntsman Cancer Institute at the University of Utah | Primary Children’s Hospital

Joaquim Farinhas, MD, MBA ф

Moffitt Cancer Center

Douglas Harrison, MD ‡ €

The University of Texas MD Anderson Cancer Center

Frederick Huang, MD ‡ €

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine | St. Louis Children’s Hospital

Susan Kreissman, MD €

Duke Cancer Institute | Duke Children's Hospital & Health Center

Margaret Macy, MD €

University of Colorado Cancer Center | Children’s Hospital Colorado

Brian Na, MD ‡ € Y

UCLA Jonsson Comprehensive Cancer Center | UCLA Mattel Children’s Hospital

Praveen Pendyala, MD §

Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute | Cleveland Clinic Children’s

Navin Pinto, MD €

Fred Hutchinson Cancer Center | Seattle Children's Hospital

Stephanie Polites, MD, MPH ¶

Mayo Clinic Comprehensive Cancer Center

Raja Rabah, MD ≠

University of Michigan Rogel Cancer Center | C.S. Mott Children’s Hospital

Hiroyuki Shimada, MD ≠

Stanford Cancer Institute | Lucile Packard Children’s Hospital

Leonora Slatnick, MD ‡

Huntsman Cancer Institute at the University of Utah | Primary Children’s Hospital

Elizabeth Sokol, MD ‡ €

Robert H. Lurie Comprehensive Cancer Center of Northwestern University | Ann & Robert H. Lurie Children’s Hospital of Chicago

Clare Twist, MD €

Roswell Park Comprehensive Cancer Center | Roswell Park Oishei Children's Cancer and Blood Disorders Program

Kieuhoa Vo, MD €

UCSF Helen Diller Family Comprehensive Cancer Center | UCSF Benioff Children’s Hospital

Tanya Watt, MD €

UT Southwestern Simmons Comprehensive Cancer Center | Children’s Medical Center Dallas

Suzanne Wolden, MD §

Memorial Sloan Kettering Cancer Center

Peter Zage, MD, PhD ‡ €

UC San Diego Moores Cancer Center | Rady Children's Hospital-San Diego

NCCN

Lisa Hang, PhD

 

Ryan Schonfeld, BA

4.临床试验（Clinical Trials）：

NCCN认为任何癌症患者都可以在临床试验中得到最佳治疗，因此特别鼓励患者参与临床试验。 寻找NCCN成员组：https://www.nccn.org/home/member-institutions

5.NCCN对证据和共识分类（ NCCN Categories of Evidence and Consensus）：

推荐均为2A类，除非另有说明，请参见下表：

	NCCN 对证据和共识的分类
1类	基于高水平证据，NCCN一致认为此项治疗合理
2A类	基于低水平证据，NCCN一致认为此项治疗合理
2B类	基于低水平证据，NCCN基本认为此项治疗合理
3类	基于任何水平证据，NCCN对此项治疗是否合理存在重大分歧

6.NCCN首选分类（ NCCN Categories of Preference）：

所有建议均视为合理，请参见下表：

	NCCN 优先使用分类
首选干预方法	若合适，可负担，则基于疗效、安全性和证据更优的干预方法
推荐的其他干预方法	其他繁育方法可能疗效较低，毒性更多，或一句的数据不太成熟；或者具有相似疗效，但费用明显较高
某些情况下有用	其他干预方法可能会用于选定的患者人群（根据推荐类型定义）